Griffin was forced off the court in the fourth quarter after he landed awkwardly under the weight of team-mate Austin Rivers.
Replays appeared to show Griffin’s left knee twist at an awkward angle and he was forced to miss the remainder of the match.
The 28-year-old made his way to the locker room with his leg elevated and was shaking his head as if to imply if knew it wasn’t going to be good news.
ESPN’s Arash Markazi spoke to Clippers owner Steve Ballmer after the game to get the latest on Griffin’s injury and while he said it is too early to tell the extent of the damage, he is “concerned”.
Doc Rivers confirmed Griffin went out of the game with a left knee injury and the power forward will be evaluated tomorrow.
“They’re going to evaluate him tomorrow and we’ll have to wait and see,” Rivers said.
“It didn’t look good but we just have to wait and see.”
Griffin has been instrumental for the Clippers this season ever since Chris Paul left to join the Houston Rockets.
He is averaging 23.4 points, 7.7 rebounds and five assists in 35.8 minutes a night.
Griffin’s entire NBA career has been blighted by injury trouble and in the two seasons prior to this campaign, he missed 66 out of 162 games.