The Brazilian playmaker completed a £142 million move to Barcelona on Monday, meaning Juergen Klopp’s “fab four” up front is now just a three.
City will look to repeat their dominant 5-0 victory over Liverpool at the Etihad in September, although they will be without injured striker Gabriel Jesus, who scored a brace that day.
Second-placed Manchester United host Stoke City on Monday, the visitors currently without a coach after sacking Mark Hughes following their FA Cup defeat by League Two Coventry City.
Jose Mourinho has been embroiled in a war of words with Chelsea coach Antonio Conte, whose side host Leicester City on Saturday when a victory would see them provisionally move above United into second.
Tottenham host Everton on Saturday and Arsenal travel to Bournemouth on Sunday. Crystal Palace face Burnley, Huddersfield meet West Ham United and Newcastle United entertain Swansea City in other weekend matches.