The 36-year-old made an incredible comeback from a serious knee injury, which kept him sidelined for seven months, but he has not featured since Boxing Day and Jose Mourinho admits the striker is “not totally happy” with his fitness.
United are looking to extend their unbeaten run to six matches in all competitions, with Mourinho’s men keeping clean sheets in their last three games – against Southampton, Everton and Derby.
The hosts expect full-back Antonio Valencia to recover in time from a hamstring injury and take his place in the starting XI, but Eric Bailly and Michael Carrick are still sidelined.
Stoke will play their first match since the sacking of Mark Hughes, after losing their last three matches and scoring just one goal in that time, with coach Eddie Niedzwiecki expected to be in temporary charge.
The Potters away form will be a concern for the players and fans alike, with no wins in their last seven on the road and Stoke sat in the bottom three going into the clash at Old Trafford.
Erik Pieters and Bruno Martins Indi both missed the FA Cup defeat at Coventry, due to hamstring and groin problems respectively, but they are expected to feature on Monday after returning to training this week.
Ryan Shawcross could face his former club after making good progress from a calf injury, while new capture Moritz Bauer is expected to make his debut at right-back after completing his switch from Rubin Kazan.